ABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinical effects of composite salvia injection (CSI) matched with western medicine (WM) in treating diabetic foot.</p><p><b>METHODS</b>Seventy-two patients, whose diagnosis were confirmed to be diabetic foot, were randomly divided and equally distributed into the comprehensive CSI plus WM treated group and the WM control group, they were treated with the CSI and WM treatment and the conventional WM respectively. The therapeutic effect was evaluated in combining with data of electromyogram and hemorrheologic investigation.</p><p><b>RESULTS</b>All the indexes were improved to various extent after treatment in both groups, but there was more significant in the CSI group than in the WM group, shown as quickening of motor and sensory nerve conduction velocity of median nerve and lowering of blood viscosity, as compared with those before treatment, P < 0.01.</p><p><b>CONCLUSION</b>CSI matched with WM in treating diabetic foot is beneficial for resulting in better effect.</p>
Subject(s)
Aged , Female , Humans , Male , Middle Aged , Diabetes Mellitus, Type 2 , Drug Therapy , Diabetic Foot , Drug Therapy , Drugs, Chinese Herbal , Therapeutic Uses , Infusions, Intravenous , Insulin , Therapeutic Uses , Phytotherapy , Salvia miltiorrhizaABSTRACT
The changes of interstitial cells of Cajal(ICC)distribution and connexin 43(Cx43)expression in gastric muscle layers were assayed in gastroparesis models of streptozotocin-induced diabetic rats.The results showed that gastric emptying was significantly delayed,the contraction frequency and amplitude of gastric muscle segments were greatly decreased,Cx43 gray values were significantly increased and Cx43 distributed homogeneously with ICC immunopositivity in the model rats.These changes appear to be related to the pathogenesis of diabetic gastroparesis.